2, 4–10, 17, 26 Ciprofloxacin is contraindicated in horses due to poor PO absorption and possible severe colitis.Įnrofloxacin and its metabolite, ciprofloxacin, can be detected in equine mane and tail hairs at least 9 months after a 2-week course of treatment.
Although the pharmacokinetics and pharmacodynamics of a number of fluoroquinolones have been reported in horses (e.g., marbofloxacin, orbifloxacin), 4, 13, 15, 23 only enrofloxacin is widely used in equine dermatology (see Table 4-1). 2, 4–10, 17 They are concentrated intracellularly in phagocytes. VMD, in Equine Dermatology (Second Edition), 2011 Fluoroquinolonesįluoroquinolones are bactericidal, broad-spectrum, concentration-dependent antibiotics with a long postantibiotic effect. Enrofloxacin is also used in most exotic animal species because of its safety and activity against a wide variety of pathogens.ĭanny W. It is also approved for treatment of bovine respiratory disease (BRD) associated with Mannheimia haemolytica, P. It is approved in weaned pigs where colibacillosis associated with E. Enrofloxacin is approved for the treatment and control of swine respiratory disease (SRD) associated with Actinobacillus pleuropneumoniae, Pasteurella multocida, Haemophilus parasuis, and Streptococcus suis. In horses, it has been used for a variety of soft tissue infections and respiratory infections, although this use is based primarily on anecdotal experience. However, it is not effective for treating Ehrlichia infections (see Doxycycline). Enrofloxacin has been shown effective for treating Rickettsia infections in dogs.
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Treatment has included infections of skin and soft tissue, urinary tract infections in dogs and cats, Chlamydophila felis infections in cats, and ulcerative colitis caused by E. Papich DVM, MS, DACVCP, in Papich Handbook of Veterinary Drugs (Fifth Edition), 2021 Indications and Clinical UsesĮnrofloxacin, like other fluoroquinolones, is used to treat susceptible bacteria in a variety of species.
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